Figure 5. Responses of Mermaid2 to simulated spike trains.

A, representative responses of Mermaid2 to voltage commands consisting of spike trains at four different frequencies (50–200 Hz). Each trace represents a single trial (not time-averaged data) from a single cell. Data were low-pass filtered offline at 0.7 kHz to reduce noise. B, analysis of responses of Mermaid2 to the spike trains. Blue, green, purple and red plots represent the power spectra of the responses to action potential trains with frequencies of 50, 100, 150 and 200 Hz, respectively. Data from 6 cells are superimposed, and the thick lines represent averages. Filled squares (top) represent the time lag for the Mermaid2 response at each spike frequency, measured by cross-correlating the Mermaid2 response with the voltage command.