Table 1.
Influence of transmural pressure on parameters of the active lymph pump in rat thoracic duct (control and after administration of ODQ and SNAP)
| Transmural pressure (cm H2O) | Treatment | Diastolic diameter (±μ) | Systolic diameter (±μ) | LPF (nl min−1) |
|---|---|---|---|---|
| 1 | Control | 761 ± 45 | 494 ± 34 | 1866 ± 379 |
| SNAP 100 μm | 785 ± 39 | 548 ± 45 | 1021 ± 297 | |
| ODQ 30 μm | 714 ± 46 | 583 ± 39 | 2039 ± 503 | |
| ODQ + SNAP | 696 ± 43 | 578 ± 41 | 1771 ± 506 | |
| 3 | Control | 801 ± 43 | 626 ± 48 | 3202 ± 431 |
| SNAP 100 μm | 829 ± 41 | 672 ± 37 | 2301 ± 438 | |
| ODQ 30 μm | 764 ± 40 | 695 ± 51 | 1646 ± 421 | |
| ODQ + SNAP | 753 ± 39 | 664 ± 45 | 2185 ± 495 | |
| 5 | Control | 808 ± 40 | 706 ± 41 | 2151 ± 276 |
| SNAP 100 μm | 841 ± 43 | 741 ± 46 | 1680 ± 312 | |
| ODQ 30 μm | 779 ± 41 | 736 ± 47 | 1087 ± 235 | |
| ODQ + SNAP | 764 ± 39 | 711 ± 47 | 1334 ± 269 |
LPF, lymphatic pump flow; ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; SNAP, nitric oxide donor S-nitroso-N-acetyl-penicillamine. Values are means ± SEM; n= 9.