Table 4.
Influence of imposed flow pressure gradients on parameters of active lymph pump in rat thoracic duct (control and after administration of the cyclic guanosine monophosphate-dependent protein kinase inhibitor, Rp-8-Br-PET-cGMPS)
| Imposed flow gradient (cm H2O) | Treatment | Diastolic diameter (±μ) | Systolic diameter (±μ) | LPF (nl min−1) |
|---|---|---|---|---|
| 0 | Control | 638 ± 43 | 485 ± 38 | 2336 ± 314 |
| Rp-8-Br-PET-cGMPS 10 μm | 579 ± 37 | 496 ± 33 | 1538 ± 291 | |
| Rp-8-Br-PET-cGMPS 50 μm | 593 ± 39 | 511 ± 34 | 1461 ± 256 | |
| Control | 647 ± 43 | 538 ± 44 | 1537 ± 302 | |
| Rp-8-Br-PET-cGMPS 10 μm | 586 ± 38 | 513 ± 34 | 1367 ± 277 | |
| Rp-8-Br-PET-cGMPS 50 μm | 598 ± 40 | 525 ± 40 | 1277 ± 216 | |
| 3 | Control | 652 ± 44 | 559 ± 43 | 1151 ± 323 |
| Rp-8-Br-PET-cGMPS 10 μm | 606 ± 39 | 524 ± 36 | 1480 ± 270 | |
| Rp-8-Br-PET-cGMPS 50 μm | 608 ± 40 | 529 ± 40 | 1320 ± 198 | |
| 5 | Control | 654 ± 45 | 552 ± 43 | 823 ± 265 |
| Rp-8-Br-PET-cGMPS 10 μm | 616 ± 43 | 513 ± 39 | 1592 ± 323 | |
| Rp-8-Br-PET-cGMPS 50 μm | 616 ± 41 | 526 ± 41 | 1295 ± 223 |
LPF, lymphatic pump flow; Rp-8-Br-PET-cGMPS, guanosine 3′,5′-cyclic monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-isomer, triethylammonium salt. Values are means ± SEM; n= 7.