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. 2013 Sep 8;174(1):172–178. doi: 10.1111/cei.12158

Fig. 5.

Fig. 5

CD8+ T cell exhaustion and function markers are studied before and after splenectomy. (a) Dual programmed death 1 (PD-1)+ and T cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) expression is decreased following splenectomy, while interferon (IFN)-γ production is increased compared to pre-splenectomy. (b) The frequency of the ligands PD-L2 and galectin-9-expressing monocytes (CD14+) is decreased following splenectomy compared to pre-splenectomy. (c) The frequency of PD-L2 and galectin-9 on dendritic cells (CD11c+) is decreased following splenectomy. *P < 0·01 and **P < 0·05.