Figure 4.

DAergic signaling is not altered in Leu9’Ala mice compared to WT mice. Locomotor activity was measure 90 minutes after administration of saline (i.p., n=6), SKF (1 mg/kg, i.p., n=6), ETIC (1 mg/kg, i.p., n=6), and AMPH (5 mg/kg, i.p., n=6) in a) WT and c) Leu9’Ala. Averaged total ambulation for b) WT and d) Leu9’Ala mice after challenge of drugs from panel a and c, respectively as in Figure 3. *p<0.05 and ***p<0.001