Table 1.

Comparison of EC₅₀ values for DA release

Genotype	EC50 (mM) for Total DA release	EC50 (mM) for α4β2-mediated α-CtxMII- resistant	EC50 (mM) for α6β2-mediated α-CtxMII-sensitive
+/+ ACh	0.41 ± 0.06	0.72 ± 0.11	0.14 ± 0.04
+/Leu9′Ala ACh	0.22 ± 0.07 *	0.30 ± 0.06 *	0.13 ± 0.11
Leu9′Ala/Leu9′Ala ACh	0.14 ± 0.05 *	0.08 ± 0.05 *+	0.24 ± 0.15
+/+ Nic	2.59 ± 0.13	4.16 ± 0.33	0.91 ± 0.12
+/Leu9′Ala Nic	1.66 ± 0.15 *	1.74 ± 0.36 *	0.71 ± 0.16
Leu9′Ala/Leu9′Ala Nic	0.57 ± 0.10 *+	0.52 ± 0.12 *+	0.73 ± 0.24

^*Significantly different from +/+

⁺Significantly different from +/Leu9′Ala