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. Author manuscript; available in PMC: 2013 Sep 26.
Published in final edited form as: Stem Cells. 2011 Nov;29(11):1727–1737. doi: 10.1002/stem.720

Figure 6.

Figure 6

Overexpression of basic fibroblast growth factor and vascular endothelial growth factor (VEGF) enhances migration of endothelial cells. (A): A wound healing assay was used to assess the effect of conditioned media from mesenchymal stem cells/bone marrow stromal cells (MSCs) overexpressing growth factor, on the migration of human umbilical vein endothelial cell. Both representative pictures (phase contrast and upper panels) and quantification (n = 4) were acquired after 12 hours. Scale bar = 200 mm. (B): Unilateral hind limb ischemia was induced in nonobese diabetic/severe combined immune deficient/β-2-microglobulin-deficient mice followed by transplantation of control (open circles, n = 8) or VEGF overexpressing MSCs (n = 6, solid circles). Laser Doppler perfusion imaging was used to assess the ratio blood flow in the healthy versus affected legs. Mean group values ± SD are shown. Asterisks denote significant difference (p ≤ .05). Abbreviations: bFGF, basic fibroblast growth factor; PDGF-B, platelet derived growth factor B; TGF-β1, transforming growth factor β1; VEGF, vascular endothelial growth factor.