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. Author manuscript; available in PMC: 2013 Sep 26.
Published in final edited form as: J Alzheimers Dis. 2012;29(2):329–340. doi: 10.3233/JAD-2011-111472

Figure 1. Serum activity of substrate V degradation.

Figure 1

The sequences of insulin, amylin and Aβ1–40 along with the sequence of substrate V are shown and compared (A). Cleavage sites of Aβ1–40 by IDE (yellow) and ACE (red) are illustrated. Different amounts of serum were incubated with substrate V at 37°C for time 0 and 24 hours (24 hr) and the degradation activity assessed by the fluorescence generation (B). BV-2 condition medium (CM) was used as a positive control.