Table 2.

Comparisons among those with normal cognition, amnestic MCI and probable AD in the homebound elderly

	Normal controls N =159	Amnestic MCI N =19	Probable AD N = 16	Vas Dementia N =22
Age, year, Mean ± SD	72.0 ± 7.9	75.6 ± 8.3	80.5 ± 9.4**	73.4 ± 7.8
Female, n/total (%)	121/159 (76%)	8/16 (50%)*	12/16 (75%)	10/22 (45%)**
African American, n/total (%)	43/159 (27%)	3/16 (19%)	9/16 (56%)	7/22 (32%)
High School and above, n/total (%)	122/159 (77%)	14/16 (88%)	7/15 (47%)***	18/22 (82%)
ApoE4 , n/total (%)	34/155 (22%)	5/15 (33%)	6/16 (38%)	4/21 (19%)
BMI, Mean ± SD	30.8 ± 7.8	32.6 ± 8.8	28.5 ± 4.7	29.7 ± 3.5
Medical Condition
Diabetes, n/total (%)	48/155 (31%)	6/16 (38%)	4/16 (25%)	10/21 (48%)
Insulin use, n/total (%)	9/156 (6%)	1/16 (6%)	1/16 (6%)	0/21 (0%)
Insulin, pM/L, median (IQR)	73.2 (47.3, 119.0)	86.2 (33.8, 153.5)	73.3 (26.2, 94.8)	80.9 (42.4, 143.7)
Amylin, median, pg/ml, median (IQR)	22.3 (11.2, 43.1)	19.3 (11.8, 65.5)	18.7 (11.2, 38.9)	28.1 (10.1, 52.2)
ACE inhibitor use, n/total (%)	58/159 (36)	5/16 (31%)	6/16 (38%)	11/22 (50%)
Neuropsychological Scores
MMSE Score, mean ± SD	27.1 ± 2.5	25.9 ± 2.6*	20.7 ± 3.4***	23.5 ± 2.2***
LM Delayed Recall, mean ± SD	23.7 ± 8.8	13.8 ± 7.9***	5.9 ± 5.7***	12.7 ± 7.7***
WLL Delayed Recall, mean ± SD	5.3 ± 2.8	1.9 ± 2.0***	0.9 ± 1.3***	1.9 ± 2.2***
Trails B, mean ± SD	147.0 ± 68.3	164.7 ± 81.1	284.5 ± 37.3***	245.4 ± 70.2***
Brain Volumes
Total brain volume, L, mean ± SD	1.1 ± 0.1	1.0 ± 0.1	1.0 ± 0.1	1.0 ± 0.1
With large vessel infarcts, n/total (%)	11/151 (7%)	0/16 (0%)	1/17 (7%)	8/21 (38%)***
With small vessel infarcts, n/total (%)	24/151 (16%)	0/16 (0%)	1/15 (7%)	12/21 (57%)***
Hippocampal volume, ml, mean ± SD	5.2 ± 0.8	5.4 ± 1.0	4.3 ± 0.8**	5.1 ± 0.8
Amygdala volume, ml, mean ± SD	4.0 ± 0.8	3.9 ± 0.9	2.8 ± 0.6***	4.0 ± 0.9

Mean ± SD with t Test or n/total (%) with Chi-Square test is presented. To compared with subjects with normal cognition,

^*P ≤ 0.05;

^**P ≤ 0.001;

^***P ≤ 0.0001 are shown for significance