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. 2013 Oct;136(10):3062–3075. doi: 10.1093/brain/awt239

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© The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlation between clinical efficacy and effects of stimulation at near postural tremor frequency (f_T). Relationship between maximal tremor suppression during DBS at f_T Hz and per cent improvement in essential tremor (ET) severity during high frequency DBS with respect to tremor severity pre-DBS implantation. Clinical rating score was the Bain and Findley tremor rating score (Bain et al., 1993). Linear regression fit is given by thick black line and its 95% confidence limits by thin black lines (F-statistic P = 0.01 and R² statistic is 0.7405). This correlation suggests that clinical efficacy and the effects of stimulation at f_T may share a common physiological basis.