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. Author manuscript; available in PMC: 2013 Sep 26.
Published in final edited form as: Cancer Genet. 2012 Jul-Aug;205(0):391–404. doi: 10.1016/j.cancergen.2012.05.012

Figure 2. CEBPB in Ewing Sarcoma.

Figure 2

Panel A shows OncoScan™ FFPE Express probes with focal 11 copy number gain of CEBPB located within larger trisomy 20q in sample EWS-19. Panel B displays CEBPB IHC for same sample, note the extremely intense and diffuse nuclear staining in EWS-19 (Copy number 11) compared to the relatively strong nuclear staining in EWS-32 (ES tumor with 3 copies), and two ES tumors with less diffuse, lighter staining and normal CEBPB copy number (EWS-44 and EWS-27). Panels C and D display the event-free survival and overall survival for the Ewing sarcoma patients within our Utah cohort with and without the focal 20q13.13 gain that contains the CEBPB gene (P=.012, P=.00013, respectively).