Table 2.
Recurrent CNAs including high gains and homozygous losses.
| PRIMARY TUMORS (N=40) | REGION | EVENT | LENGTH (Kilobases, KB) | PERCENTAGE |
|---|---|---|---|---|
| CHROMOSOME 1 | 1q21.1-qter | CN Gain/2 High Copy Gains | 104529 KB | 17.5% (7/40) |
| 1q21.2 | High Copy Gain | 956 KB | 2.5% (1/40) | |
| CHROMOSOME 2 | 2p25.3-pcen | CN Gain | 89915 KB | 5% (2/40) |
| 2q11.1-qter | CN Gain | 147991 KB | 5% (2/40) | |
| CHROMOSOME 5 | 5p15.33-pcen | CN Gain | 46368 KB | 10% (4/40) |
| 5q11.1-qter | CN Gain | 131261 KB | 7.5% (3/40) | |
| 5q34 | Homozygous Copy Loss | 127 KB | 2.5% (1/40) | |
| 5q35.1 | High Copy Gain | 537 KB | 2.5% (1/40) | |
| CHROMOSOME 6 | 6p25.3 | High Copy Gain | 501 KB | 2.5% (1/40) |
| 6p22.3 | High Copy Gain | 1343 KB | 2.5% (1/40) | |
| 6p22.2-p22.1 | High Copy Gain | 727 KB | 2.5% (1/40) | |
| CHROMOSOME 7 | 7q11.1-qter | CN Gain | 97752 KB | 5% (2/40) |
| CHROMOSOME 8 | 8p23.3-pcen | CN Gain (includes 1 focal High Gain within Full Gain) | 43868 KB | 35% (14/40) |
| 8q11.1-qter | CN Gain/1 High Copy Gain (includes 1 shorter CN Gain) | 99153 KB | 37.5% (15/40) | |
| CHROMOSOME 9 | 9q31.3-qter | CN Gain | 28340 KB | 5% (2/40) |
| 9p24.1 | Homozygous Copy Loss | 43 KB | 2.5% (1/40) | |
| 9p21.3 | Homozygous Copy Loss | 115 KB | 5% (2/40) | |
| CHROMOSOME 12 | 12p13.33-pcen | CN Gain | 35400 KB | 12.5% (5/40) |
| 12q11.-qter | CN Gain | 95605 KB | 12.5% (5/40) | |
| CHROMSOME 13 | 13q13.1 | CN Gain/1 High Copy Gain | 49 KB | 5% (2/40) |
| CHROMOSOME 14 | 14q11.2-qter | CN Gain | 86854 KB | 7.5% (3/40) |
| CHROMOSOME 16 | 16q11.2-qter | CN Loss | 43685 KB | 10% (4/40) |
| CHROMOSOME 18 | 18q12.1 | High Copy Gain | 871 KB | 2.5% (1/40) |
| CHROMOSOME 20 | 20p13-pcen | CN Gain | 27100 KB | 10% (4/40) |
| 20q11.21-qter | CN Gain (includes 1 focal High Gain within Full Gain) | 33075 KB | 15% (6/40) | |
| 20q13.2 | High Copy Gain | 389 KB | 2.5% (1/40) | |
| CHROMOSOME 21 | 21q11.1-qter | CN Gain | 33279 KB | 10% (4/40) |
| CHROMOSOME 22 | 22q12.2-qter | CN Gain | 21656 KB | 5% (2/40) |
| 22q11.23 | Homozygous Copy Loss | 53 KB | 5% (2/40) | |
| 22q13.31-q13.33 | Homozygous Copy Loss | 3166 KB | 2.5% (1/40) | |
| METASTATIC LESIONS (N=12) | ||||
| CHROMOSOME 1 | 1q21.1-qter | CN Gain | 104529 KB | 5% (2/40) |
| CHROMOSOME 2 | 2p25.3-pcen | CN Gain | 89915 KB | 5% (2/40) |
| CHROMOSOME 5 | 5q11.2 | High Copy Gain | 309 KB | 2.5% (1/40) |
| CHROMOSOME 6 | 6p25.3 | High Copy Gain | 501 KB | 2.5% (1/40) |
| 6p22.3 | High Copy Gain | 890 KB | 2.5% (1/40) | |
| CHROMOSOME 7 | q22.1-q31.1 | CN Gain | 500 KB | 5% (2/40) |
| CHROMOSOME 8 | 8p23.3-pcen | CN Gain/3 High Copy Gains | 43868 KB | 10% (4/40) |
| 8q11.1-qter | CN Gain/3 High Copy Gains | 99153 KB | 10% (4/40) | |
| CHROMOSOME 9 | 9q34.2-q34.3 | High Copy Gain | 923 KB | 5% (2/40) |
| CHROMOSOME 12 | 12p13.33-pcen | CN Gain/1 High Copy Gains | 35400 KB | 10% (4/40) |
| 12q11.-qter | CN Gain/1 High Copy Gains | 95605 KB | 7.5 % (3/40) | |
| CHROMOSOME 16 | 16q11.2-qter | CN Loss | 43685 KB | 5% (2/40) |
| CHROMOSOME 19 | 19p13.13 | Homozygous Copy Loss | 325 KB | 2.5% (1/40) |