Table 1.
Estimated degree of tissue sharing of cis-effects (1% FDR) using (A) a threshold-based approach and (B) a matched co-twin design comparing the p-value distributions across tissueswhereπ1 represents the proportion of true positives
| Reference tissue | Secondary tissue | A | B | |
|---|---|---|---|---|
|
| ||||
| N (%) | Twin 1 π1 | Twin 2 π1 | ||
|
| ||||
| Adipose | LCL | 1221 (34.6) | 0.64 | 0.56 |
| Skin | 1207 (34.3) | 0.79 | 0.77 | |
| LCL and Skin | 767(21.8) | - | - | |
| LCL or Skin | 1661 (47.1) | - | - | |
|
| ||||
| LCL | Adipose | 1118 (24.2) | 0.65 | 0.63 |
| Skin | 978 (21.1) | 0.65 | 0.61 | |
| Adipose and Skin | 728 (15.7) | - | - | |
| Adipose or Skin | 1368 (29.6) | - | - | |
|
| ||||
| Skin | Adipose | 1265 (45.2) | 0.77 | 0.83 |
| LCL | 1104 (39.5) | 0.64 | 0.64 | |
| Adipose and LCL | 790(28.3) | - | - | |
| Adipose or LCL | 1579 (56.5) | - | - | |