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. Author manuscript; available in PMC: 2013 Sep 26.
Published in final edited form as: Nat Genet. 2012 Sep 2;44(10):1084–1089. doi: 10.1038/ng.2394

Table 3.

Replication in independent cohorts of cis – and trans associations

Tissue Cohort N trans-hits
tested/total
hits at
P<5×10−8 		P<0.05* π 1 cis-hits
tested/total
hits at 1%
FDR		 P<0.05* π 1
Adipose
(subcutaneous
)		 Decode 585 586/639 25/586
(4.3%)		 0.10 NA NA NA
Adipose
(subcutaneous
)		 MGH 701 514/639 27/514
(5.3%)		 0.096 2980/3332 1751/2980
(59%)		 0.79
LCL ALSPAC 931 544/557 33/544
(6.1%)		 0.13 6181/6289 4154/6181
(67%)		 0.76
LCL Oxford
(TwinsUK)		 331 361/557 23/361
(6.4%)		 0.13 4608/6289 2745/4608
(60%)		 0.75
Skin
(fibroblasts)		 GenCORD 68 442/609 15/442
(3.4%)		 0.00024 2241/3416 455/2241
(20%)		 0.34
*

consistent direction