Table 3.

Hepatic gene expression in mice after high fat feeding.

	WT	SMS2LTg	WT	SMS2 KO
TG and DAG hydrolysis
HSL	100±41	95±36	100±37	199±59
ATGL	100±31	136±27	100±43	109±37
FFA oxidation
AOX	100±28	145±31	100±44	113±53
CPT1	100±37	141±66	100±18	94±19
PPARα	100±37	149±42	100±28	188±54
FFA uptake and transport
PPARγ1	100±11	114±20	100±23	81±22
PPARγ2	100±40	209±31*	100±33	31±9*
CD36	100±21	370±56*	100±29	52±15*
FSP27	100±27	582±102*	100±20	39±14*
Lipid synthesis and storage
FAS	100±16	126±36	100±73	76±32
SREBP1c	100±11	74±10	100±43	135±60
DGAT1	100±31	173±36*	100±54	143±52
DGAT2	100±45	183±41*	100±58	159±37
Mitochondrial bioenergetic/lipid metabolism
UCP2	100±21	78±48	100±51	75±9

HSL, hormone-sensitive lipase; ATGL, adipose triglyceride lipase; AOX, acyl-CoA oxidase; CPT1, Carnitine palmitoyltransferase; PPAR, peroxisome proliferator-activated receptor; FAS27, Fat-specific protein of 27 kDa; FAS, fatty acid synthase; SREBP, sterol-responsive element-binding protein; DGAT, diacylglycerol acyltransferase; UCP1, uncoupling protein 1, or UCP1. Value: mean±SD; n=4. FFA, free fatty acids.

^*P<0.01.