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Structure-activity relationship of D-glucose as a substrate for the GLUT-1 transporter. Substitutions at C1, C2, and C6 have been most explored to date, demonstrating that some substitutions can be made with the resulting conjugate retaining affinity for GLUT-1. Substitutions at C3 and C4 require further study; to date, no C3- or C4-glucose-conjugated anticancer compounds have been reported.
