Table 3.
Overall and adjusted HRs for CVD according to RT at baseline and stratified by laterality
RT and laterality | Total, n | With CVD, n | Woman-years | Crude rates (per 1,000 woman-years) |
Crude HR (95% CI) |
Adjusted HRa (95% CI) |
Adjusted HRb (95% CI) |
---|---|---|---|---|---|---|---|
Radiation yes, left side vs. |
443 | 88 | 1,441 | 61.07 | 0.86 (0.65–1.14) | 0.97 (0.72–1.31) | 1.00 (0.75–1.35) |
Radiation no, left side |
125 | 1,564 | 79.92 | 1.00 (ref) | ref | ||
Radiation yes, right side vs. |
363 | 48 | 1,094 | 43.88 | 0.63 (0.45–0.88) | 0.73 (0.52–1.05) | 0.75 (0.53–1.06) |
Radiation no, right side |
120 | 1,542 | 77.82 | 1.00 (ref) | ref | ||
Radiation yes, left side vs. |
340 | 88 | 1,441 | 61.07 | 1.42 (0.99–2.03) | 1.54 (1.07–2.23) | 1.53 (1.06–2.21) |
Radiation yes, right side |
48 | 1,094 | 43.88 | 1.00 (ref) | ref | ||
Radiation no, left side vs. |
466 | 125 | 1,564 | 79.92 | 1.03 (0.80–1.32) | 1.17 (0.91–1.51) | 1.14 (0.88–1.47) |
Radiation no, right side |
120 | 1,542 | 77.82 | 1.00 (ref) | ref |
Fully adjusted model includes age, year, and stage of breast cancer diagnosis, race, ER/PR status, health plan, diabetes, and hypertension.
Parsimonious model is adjusted for the same variables excluding year of diagnosis, health plan, and breast cancer stage at diagnosis.