Table 2.
Brain Harmane Concentrations in Study Subjects
| ET (n=70) Geometric mean (95% CI) | Controls (n=27) Geometric mean (95% CI) | P-value | ||
|---|---|---|---|---|
| Unadjusted | 0.9950 (0.8578, 1.1541) | 0.9108 (0.7933,1.0456) | 0.38 | |
| Unadjusteda | 1.0025 (0.8630 – 1.1645) | 0.8938 (0.7716 – 1.0353) | 0.27 | |
| Covariate Adjusteda,b | 1.0824 (0.9405 – 1.2457) | 0.8037 (0.6967 – 0.9272) | 0.004 | |
| ET + FH (n = 23) | ET – FH (n=47) | Controls (n = 27) | ||
| Unadjusted | 1.0456 (0.7568, 1.4446) | 0.9711 (0.8243, 1.1440) | 0.9108 (0.7933,1.0456) | 0.98 |
| Unadjusteda | 1.0731 (0.7680 – 1.4994) | 0.9711 (0.8243 – 1.1440) | 0.8938 (0.7716 – 1.0353) | 0.96 |
| Covariate Adjusteda,b | 1.2005 (0.8712 – 1.6541) | 1.0312 (0.8879 – 1.1976) | 0.8037 (0.6967 – 0.9272) | 0.054 |
FH = family history of tremor.
a
Two controls with missing data on freezer time and one ET case with family history and missing data on PMI were excluded from the analysis.
b
Adjustment for PMI and freezer time.
p-value from t-test for difference between two groups and Kruskal-Wallis test for difference among three groups.