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. 2013 Sep 26;8(9):e74923. doi: 10.1371/journal.pone.0074923

Figure 5. FHOD1 silencing significantly reduces the motility and invasiveness of UT-SCC-43B cells.

Figure 5

UT-SCC-43B cells were treated with FHOD1 or control siRNA and subjected to wound healing assay and a Matrigel invasion assay. A) The wound of control cells has fully healed by 24 h, whereas the wound in siRNA treated cells is only partially healed. B) A graph showing the healing process at different time points. Bars indicate standard error of mean. Interaction between time and group are statistically significant (*** P<0.0001). The difference is statistically significant at every time point (P<0.002). n = 4 in each group. C) In a 72 hour Matrigel invasion assay, invasion is significantly reduced in FHOD1-deficient cells when compared to control siRNA treated cells. (* P<0.05) n = 3–5 in each group.