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. 2013 Sep 26;8(9):e76598. doi: 10.1371/journal.pone.0076598

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© 2013 Nölle et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Western blot analysis of brain lysates from AD (Braak stage 5-6) and control (Braak stage 1) brain material using an ubiquilin 2 antibody and a GAPDH antibody as loading control. (B) Quantification of Western blot signals in (A). Ubiquilin 2 signals were normalized to GAPDH and statistically analysed (Mann–Whitney test, * p <0.05). (C) Supernatant and pellet lysate fractions of brain material from 3 AD patients (Braak stage 6) and 3 controls (Braak stage 1) were analysed by Western blotting. Pellets were treated with formic acid to dissolve aggregates prior to Western blotting. GAPDH was used as loading control (supernatant); tau was used as a control for successful extraction of the aggregates in the AD samples (pellet). AD, Alzheimer’s disease.