Table 3. Semi-quantitative analysis of AD cases double-stained with ubiquilin 2 and AT8.
| Number of cells | AT8 positive | AT8 negative | z | p value | AT8 positive |
|---|---|---|---|---|---|
| Sum (case 2-8) | |||||
| Ubiquilin 2 low | 109 | 227 | 12.28 | 0.00045784 | Decrease |
| Ubiquilin high | 87 | 110 | |||
| Case 2 | |||||
| Ubiquilin 2 low | 14 | 30 | 34.10 | 5.2351E-09 | Decrease |
| Ubiquilin high | 26 | 10 | |||
| Case 3 | |||||
| Ubiquilin 2 low | 29 | 22 | 0.10 | 0.75363717 | ns |
| Ubiquilin high | 15 | 13 | |||
| Case 4 | |||||
| Ubiquilin 2 low | 11 | 44 | 0.00 | 1 | ns |
| Ubiquilin high | 4 | 18 | |||
| Case 5 | |||||
| Ubiquilin 2 low | 9 | 33 | 3.49 | 0.06190065 | ns |
| Ubiquilin high | 11 | 18 | |||
| Case 6 | |||||
| Ubiquilin 2 low | 36 | 32 | 31.50 | 1.9944E-08 | Increase |
| Ubiquilin high | 6 | 43 | |||
| Case 7 | |||||
| Ubiquilin 2 low | 4 | 40 | 48.43 | 3.4171E-12 | Decrease |
| Ubiquilin high | 14 | 7 | |||
| Case 8 | |||||
| Ubiquilin 2 low | 6 | 26 | 106.25 | 6.4996E-25 | Decrease |
| Ubiquilin high | 11 | 1 |
Ubiquilin 2 low indicates number of cells with low or no ubiquilin 2 staining, and ubiquilin 2 high indicates number of cells with high ubiquilin 2 staining. Frequency distributions were compared between cells with AT8 staining (AT8 positive) and without AT8 staining (AT8 negative) using a chi-square test. The right column indicates a significant decrease or increase of the number of ubiquilin 2 low cells in the AT8 positive group. ns, non significant.