Table 3. Subgroup analysis of the association between MGMT promoter methylation and NSCLC.
| Tumor |
Control |
M-H pooled ORb
|
D+L pooled ORa
|
Heterogeneity |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Group | M+ | N | M+ | N | OR (95%CI) | OR (95%CI) | I 2 (%) | P | τ2 |
| Control group | |||||||||
| Auologous | 202 | 818 | 69 | 810 | 4.16 (3.02, 5.72) | 3.74 (2.54, 5.51) | 16.6 | 0.276 | 0.080 |
| Heterogeneous | 93 | 342 | 0 | 160 | 20.45 (5.83, 71.73) | 11.18 (2.14, 58.35) | 34.0 | 0.194 | 1.208 |
| Ethnicity | |||||||||
| Asian | 92 | 515 | 6 | 405 | 10.96 (5.20, 23.14) | 7.36 (2.33, 23.19) | 45.1 | 0.105 | 0.8807 |
| Caucasian | 203 | 645 | 63 | 565 | 4.00 (2.85, 5.60) | 3.49 (2.37, 5.14) | 8.9 | 0.358 | 0.0418 |
| Method | |||||||||
| MSP | 214 | 939 | 46 | 821 | 6.17 (4.28, 8.91) | 5.31 (3.00, 9.41) | 40.2 | 0.060 | 0.4155 |
| Q-MSP | 81 | 221 | 23 | 149 | 3.06 (1.75, 5.33) | 2.84 (1.62, 5.00) | 0.0 | 0.674 | <0.0001 |
| Total | 295 | 1160 | 69 | 970 | 5.10 (3.77, 6.91) | 4.43 (2.85, 6.89) | 32.0 | 0.095 | 0.2476 |
D+L pooled ORa: the result from random-effects model;M-H pooled ORb: the result from fixed-effects model.