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. 2013 Sep 24;123(10):4195–4207. doi: 10.1172/JCI62891

Figure 9. Targeting the SALL4/MLL/HOXA9 pathway in AML.

Figure 9

SALL4 can upregulate HOXA9 expression by interacting with MLL, which results in H3K4 and H3K79 methylation. The SALL4/MLL/HOXA9 pathway is critical for leukemic cell survival, as disruption of this pathway results in leukemic cell death. Based on this model, we propose the following novel therapeutic approaches in targeting AML: (i) inhibiting the function of MLL and its complex (MLL inhibitor); (ii) disrupting the SALL4/MLL interaction; and (iii) targeting HOXA9 (HOXA9 inhibitor).