Figure 4. I/R injury is increased in mice with CM-specific reduction of β1 integrins.

(A and B) Representative Western blot and immunofluorescent analyses for β1D integrin protein in the MCM-Itgb1^fl/fl mice 4 weeks after tamoxifen injection show significant reductions in integrin expression compared with MCM-Itgb1^fl/fl mice injected with diluent only. Scale bar: 100 μm. (C) Representative sections of TTC-stained hearts. (D) Quantification performed by normalizing the area at risk to LV area and myocardial infarct area to the area at risk. *P < 0.05 vs. littermate control, n = 6 per group (1-way ANOVA).