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. 2013 Sep 9;123(10):4170–4181. doi: 10.1172/JCI67315

Figure 6. Nutlin-3 inhibits capillary tube formation.

Figure 6

(A) HUVECs were seeded on Matrigel matrix and incubated with FGF-2 and 7.5 μM of Nutlin-3A, 5 μM of Nutlin-3A, 7.5 μM of Nutlin-3B, or vehicle (DMSO). The images were taken with an inverted light microscope and are representative of capillary tube formation at 24 hours. Original magnification, ×100. (B) Quantification of Nutlin-3A–mediated capillary tube formation inhibition. Results are expressed as a ratio of tubule length measured to total area examined ± SEM. *P < 0.05.