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. 2013 Sep 9;123(10):4170–4181. doi: 10.1172/JCI67315

Figure 9. Nutlin-3 does not target preexisting blood vessels.

Figure 9

(A and B) Adult mice received a single intravitreal injection of Nutlin-3 or DMSO to investigate the effects of Nutlin-3 on established blood vessels. (A) Confocal images of GS-IB4 lectin–stained and (B) H&E-stained paraffin-embedded sections of retinal vasculature 5 days after injection. Scale bars: 500 μm (A); 100 μm (B).(C) Quantification of retinal vessels shows no difference between sham- (n = 8) and Nutlin-3–injected mice (n = 8) Data represent mean ± SD. NS, P > 0.05, summation of 2 independent experiments.