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. 2013 Sep 24;123(10):4513–4524. doi: 10.1172/JCI68807

Figure 4. Increased insulin clearance in humans with the risk allele of SLC30A8.

Figure 4

(A–F) Concentration (A, C, and E) and AUC 0–180 minutes (B, D, and F) of insulin (A and B), c-peptide (C and D), and glucose (E and F) during 75-g oral GTT in human nonrisk (n = 42) and risk (n = 12) allele groups. (G) c-peptide/insulin ratio at 30 minutes of human 75-g oral GTT. (H) GIR during glucose clamp at each insulin infusion rate. (I) MCR-I at steady state during the infusion of exogenous insulin at 10 or 20 mU/m2/min. (J) Insulinogenic index, calculated as change in insulin (0–30 minutes) relative to change in glucose (0–30 minutes). Data are mean ± SEM (A, C, E, and J) or mean ± SD (H and I). *P < 0.05, unpaired t test.