Figure 5. FKBP51 selectively promotes tau neurotoxicity.
(A) Sections from FKBP51- and GFP AAV–injected mice were stained with Gallyas silver stain and positive area (± SEM) per CA3 was measured. *P = 0.0297. Representative images of each group are shown. Scale bar: 2,000 μm; 200 μm (inset). Original magnification, ×10 (inset). (B) Neurons stained by cresyl violet and NeuN were counted (± SEM) by stereology in the CA3 region. *P = 0.0003. (C) Representative images are shown. Scale bar: 500 μm; 50 μm. Original magnification, ×20 (inset). (D) Volume of CA3 (± SEM) in injected transgenic mice was evaluated by stereology.