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. 2013 Sep 3;123(10):4158–4169. doi: 10.1172/JCI69003

Figure 7. FKBP5 DNA demethylation with aging.

Figure 7

Average FKBP5 methylation analysis of human DNA samples from the PCG of individuals aged 21, 36, 42, 74, 85, 95 years were performed on multiple CpG sites in (A) intron 7, (B) promoter, and (C) intron 2. Significant demethylation in intron 7 was found at P1_S1_Pos2 (P = 0.0012, r = 0.6506), P1_S2_Pos1 (P = 0.0007, r = 0.9585), P1_S2_Pos2 (P = 0.0039, r = 0.9002), P1_S2_Pos3 (P = 0.0240, r = 0.9002), and P1_S2_Pos3 (P = 0.0240, r = 0.7583). Methylation was significantly decreased in the promoter at GRE_S1_CG1 (P = 0.0327, r = 0.7199) and GRE3_S1_CG3 (P = 0.0216, r = 0.7698).