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. 2013 Sep 9;123(10):4410–4422. doi: 10.1172/JCI69369

Figure 3. Prostate carcinoma progression is associated with sMICB-induced impairment in NK cell peripheral maintenance.

Figure 3

(A and B) Comparisons of splenic CD8 (A) and NK (B) cells and NKG2D+ population in cohorts of 24-week-old TRAMP/MICB, TRAMP, and wild-type B6 mice. Left panel, representative dot plots of flow cytometry analyses. Right panel, pooled statistical data of flow cytometry analyses of each cohort. **P < 0.001 in comparison with TRAMP mice or with TRAMP/MICB mice that developed WD tumors. (C) Significant inverse correlation of serum sMICB with splenic NK cell population as analyzed from the cohort of 24-week-old TRAMP/MICB mice. (D) Representative dot plots of flow cytometry analyses and statistics of pooled data demonstrating systemic (LN, BM, and blood) depletion of NK cells in TRAMP/MICB mice that developed PD carcinoma. (E) Representative dot plots of flow cytometry analyses and statistical data demonstrating significant reduction of NK cells in tumor infiltrated lymphocytes (TILs) in PD tumors from TRAMP/MICB mice. All data show represents results from 3 independent assays of at least 5 animals.