Figure 7. Robust restoration of antimicrobial peptides in Il17a^–/– skin wounds by WT DETC via an IL-17A–dependent mechanism.

Wounded SOCs from WT or Il17a^–/– mice were supplemented with preactivated WT DETC. Neutralizing anti–IL-17A antibody together with preactivated DETC was added into the wound bed of SOCs. Skin directly adjacent to the wound bed was analyzed for β-defensin 3 and RegIIIγ expression (red staining). DAPI was used to visualize cell nuclei (blue staining). Dotted white lines represent the epidermal-dermal border. Scale bar: 50 μm.