Figure 3. Epilepsy pathogenicity score correlates with epilepsy phenotype. A.

The pathogenicity score of the highest scoring gene deleted is significantly higher in patients with epilepsy than those with non-neurologic indications (Wilcox Signed Rank Test, p = 5.2×10⁻⁴). This difference remains significant even when the training genes (Table S1) are not considered (Wilcox Signed Rank Test, p = 0.011). B. Genes contained within genomic duplications are not significantly different.