Table 2. Distribution of MGMT Leu84Phe genotypes and allelic frequency.

Study (year)	Distribution of MGMT Leu85Phe genotypes								Frequency of MGMT Leu85Phe alleles					HWE P value
	Case (n)				Control (n)				Case (n)			Control (n)
	CC	CT	TT		CC	CT	TT		C	T		C	T
Inoue (2003)	55	18	0		160	55	9		128	18		375	73	0.13
Krzensniak (2004)	67	23	6		74	17	5		157	35		165	27	0.01
Bigler (2005)	403	108	6		466	136	13		914	120		1068	162	0.41
Huang (2005)	190	82	8		279	99	9		462	98		657	117	0.95
Huang (2005) a	315	80	5		468	179	18		710	90		1115	215	0.86
Huang (2005) b	71	37	6		61	25	3		179	49		147	31	0.82
Li (2005)	132	34	1		173	28	3		298	36		374	34	0.15
Ritchey (2005)	123	36	2		213	32	1		282	40		458	34	0.86
Shen (2005)	778	265	21		824	263	20		1821	307		1911	303	0.85
Chae (2006)	344	84	4		341	81	10		772	92		763	101	0.06
Han (2006)	344	82	8		822	242	21		770	98		1886	284	0.52
Han (2006)	964	279	33		1306	382	26		2207	345		2994	434	0.75
Jiao (2006)	264	101	5		257	82	1		629	111		596	84	0.04
Kietthubthew (2006)	84	21	1		130	33	1		189	23		293	35	0.48
Moreno (2006)	213	47	12		225	63	11		473	71		513	85	0.02
Tranah (2006) a	147	33	6		1634	471	32		327	45		3739	535	0.77
Tranah (2006) b	204	47	6		330	93	6		455	59		753	105	0.85
Wang (2006)	832	259	30		872	272	19		1923	319		2016	310	0.67
Zienolddiny (2006)	189	102	13		247	106	10		480	128		600	126	0.73
Felini (2007)	289	84	6		369	84	6		662	96		822	96	0.63
Hall (2007)	574	198	31		764	277	21		1346	260		1805	319	0.48
Hu (2007)	418	77	5		421	93	3		913	87		935	99	0.38
Huang (2007)	372	156	11		592	198	10		900	178		1382	218	0.15
Shen (2007)	432	112	11		373	110	12		976	134		856	134	0.26
Stern (2007)	251	40	1		959	194	13		542	42		2112	220	0.37
Doecke (2008)	416	136	14		1029	281	27		968	164		2339	335	0.13
Zhang (2008)	352	53	1		631	144	7		757	55		1406	158	0.70
Hazra (2008)	271	72	15		254	97	6		614	102		605	109	0.34
Akbari (2009)	142	53	1		185	63	2		337	55		433	67	0.17
Gu (2009)	152	60	2		168	43	1		364	64		379	45	0.32
Khatami (2009)	40	160	0		61	140	0		240	160		262	140	0.00
Liu (2009)	299	62	8		267	89	7		660	78		623	103	0.89
McKean-Cowdin (2009)	774	204	20		1480	453	35		1752	244		3413	523	0.96
Yang (2009)	33	14	1		289	58	5		80	16		636	68	0.29
Agalliu (2010) a	949	269	32		916	298	23		2167	333		2130	344	0.83
Agalliu (2010) b	106	35	6		60	20	1		247	47		140	22	0.64
Huang (2010)	151	25	0		89	21	0		327	25		199	21	0.27
Palli (2010)	210	77	4		395	131	11		497	85		921	153	0.97
Zhang (2010)	563	151	7		933	284	17		1277	165		2150	318	0.38
Bye (2011) a	225	111	10		300	155	14		561	131		755	183	0.26
Bye (2011) b	120	65	11		294	116	13		305	87		704	142	0.71
Loh (2011)	146	37	5		894	212	14		329	47		2000	240	0.72
O’Mara (2011) a	889	261	23		810	270	19		2039	307		1890	308	0.52
O’Mara (2011) b	278	108	11		296	103	7		664	130		695	117	0.57

Bold indicates statistically significant P value.

HWE Hardy–Weinberg equilibrium