. 2013 Sep 26;8(9):e75367. doi: 10.1371/journal.pone.0075367

Table 4. Summary ORs (95% CI) for MGMT Leu84Phe variant categorized by ethnicity and ethnicity / tumor site under different genetic models.

MGMT Leu85Phe	N^#	TT versus CC		TT+TC versus CC		TT versus TC + CC		T versus C
				(dominant genetic model)		(recessive genetic model)
Ethnicity		OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
Caucasian	15	1.32 (1.10-1.61)	0.004	0.98 (0.90-1.06)^b	0.560	1.34 (1.11-1.62)	0.002	1.00 (0.93-1.09)^b	0.923
Caucasian in HWE	13	1.29 (1.05-1.59)	0.014	0.96 (0.88-1.06)^b	0.407	1.31 (1.07-1.61)	0.009	0.99 (0.91-1.08)^b	0.827
Asian	13	0.97 (0.58-1.61)	0.898	1.07 (0.88-1.31)^b	0.485	0.94 (0.57-1.56)	0.805	1.03 (0.86-1.22)^b	0.779
Asian in HWE	11	1.19 (0.68-2.09)	0.546	1.04 (0.83-1.30)^b	0.724	1.15 (0.65-2.01)	0.633	1.02 (0.83-1.26)^b	0.861
Mixed ethnicities	16	1.27 (1.01-1.60)	0.041	1.01 (0.91-1.13)^b	0.813	1.28 (1.02-1.61)	0.037	1.04 (0.95-1.13)^b	0.457
Mixed ethnicities in HWE	15	1.25 (0.99-1.58)	0.057	1.00 (0.90-1.12)^b	0.997	1.26 (1.00-1.58)	0.052	1.08 (0.95-1.22)^b	0.236
Caucasian
Lung cancer	3	1.62 (1.04-2.53)	0.035	1.12 (0.96-1.31)	0.159	1.57 (1.01-2.45)	0.048	1.14 (0.99-1.31)	0.061
UADT SCC	3	0.88 (0.33-2.33)^b	0.794	0.85 (0.66-1.08)^b	0.182	0.92 (0.36-2.35)^b	0.865	0.87 (0.66-1.14)^b	0.312
Asian
UADT SCC	3	0.94(01.15-5.84)	0.950	0.96(0.7101.30)	0.800	0.93 (0.15-5.76)	0.939	0.97 (0.73-1.28)	0.802
Mixed ethnicities
Colorectal cancer	4	1.46 (0.89-2.38)	0.134	0.85 (0.72-1.01)	0.059	1.53 (0.94-2.50)	0.088	0.91 (0.79-1.06)	0.220

Bold indicates statistically significant P value

All summary ORs were calculated using fixed-effects models, unless stated otherwise

# Number of studies

b Random-effect models

UADT SCC − Upper Aerodigestive Tract Squamous Cell CarcinomaHWE − Hardy Weinberg Equilibrium