Table 4. Summary ORs (95% CI) for MGMT Leu84Phe variant categorized by ethnicity and ethnicity / tumor site under different genetic models.
MGMT Leu85Phe | N# | TT versus CC |
TT+TC versus CC |
TT versus TC + CC |
T versus C |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
|
(dominant genetic model) |
(recessive genetic model) |
|
|||||||||
Ethnicity | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||||
Caucasian | 15 | 1.32 (1.10-1.61) | 0.004 | 0.98 (0.90-1.06)b | 0.560 | 1.34 (1.11-1.62) | 0.002 | 1.00 (0.93-1.09)b | 0.923 | |||
Caucasian in HWE | 13 | 1.29 (1.05-1.59) | 0.014 | 0.96 (0.88-1.06)b | 0.407 | 1.31 (1.07-1.61) | 0.009 | 0.99 (0.91-1.08)b | 0.827 | |||
Asian | 13 | 0.97 (0.58-1.61) | 0.898 | 1.07 (0.88-1.31)b | 0.485 | 0.94 (0.57-1.56) | 0.805 | 1.03 (0.86-1.22)b | 0.779 | |||
Asian in HWE | 11 | 1.19 (0.68-2.09) | 0.546 | 1.04 (0.83-1.30)b | 0.724 | 1.15 (0.65-2.01) | 0.633 | 1.02 (0.83-1.26)b | 0.861 | |||
Mixed ethnicities | 16 | 1.27 (1.01-1.60) | 0.041 | 1.01 (0.91-1.13)b | 0.813 | 1.28 (1.02-1.61) | 0.037 | 1.04 (0.95-1.13)b | 0.457 | |||
Mixed ethnicities in HWE | 15 | 1.25 (0.99-1.58) | 0.057 | 1.00 (0.90-1.12)b | 0.997 | 1.26 (1.00-1.58) | 0.052 | 1.08 (0.95-1.22)b | 0.236 | |||
Caucasian | ||||||||||||
Lung cancer | 3 | 1.62 (1.04-2.53) | 0.035 | 1.12 (0.96-1.31) | 0.159 | 1.57 (1.01-2.45) | 0.048 | 1.14 (0.99-1.31) | 0.061 | |||
UADT SCC | 3 | 0.88 (0.33-2.33)b | 0.794 | 0.85 (0.66-1.08)b | 0.182 | 0.92 (0.36-2.35)b | 0.865 | 0.87 (0.66-1.14)b | 0.312 | |||
Asian | ||||||||||||
UADT SCC | 3 | 0.94(01.15-5.84) | 0.950 | 0.96(0.7101.30) | 0.800 | 0.93 (0.15-5.76) | 0.939 | 0.97 (0.73-1.28) | 0.802 | |||
Mixed ethnicities | ||||||||||||
Colorectal cancer | 4 | 1.46 (0.89-2.38) | 0.134 | 0.85 (0.72-1.01) | 0.059 | 1.53 (0.94-2.50) | 0.088 | 0.91 (0.79-1.06) | 0.220 |
Bold indicates statistically significant P value
All summary ORs were calculated using fixed-effects models, unless stated otherwise
# Number of studies
b Random-effect models
UADT SCC − Upper Aerodigestive Tract Squamous Cell CarcinomaHWE − Hardy Weinberg Equilibrium