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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Int Forum Allergy Rhinol. 2013 Jun 3;3(9):740–747. doi: 10.1002/alr.21187

Figure 5.

Figure 5

Active proliferation of basal cells in IOI-TNFR2−/− mice. BrdU labeling was used to visualilze proliferating progenitor cells in the OE. A: Dividing cells are rare in adult mice in the absence of injury or perturbation. B: After 6 weeks of doxycycline-induced TNF-α expression in IOI mice, there are also no BrdU expression in the OE, although dividing inflammatory cells in the subepithelium may be seen. C: After doxycycline-induced TNF-α expression for 6 weeks in the IOI-TNFR2−/− mice, BrdU+ cells can be seen in the basal layer of the olfactory epithelium. Lower left panel: graph depicting differences in BrdU labeling. *p= 0.02, **p=0.03. Error bars represent standard error of the mean.