Table 1.
Pharmacokinetic parameters after a single intraperitoneal injection of ketamine (125 mg/kg) and xylazine (10 mg/kg)
| Young rats | Old rats | |
| Ketamine | ||
| AUC0-t (ng × h/mL) | 8,539.5 | 15,970.7a |
| AUCinf (ng × h/mL) | 9,422.7 | 56,927.3a |
| Kel (/h) | 0.5491 | 0.0817a |
| T1/2 (h) | 1.26 | 8.48a |
| Xylazine | ||
| AUC0-t (ng × h/mL) | 1,465.8 | 2,040.3a |
| AUCinf (ng × h/mL) | 1,666.0 | 11,168.1a |
| Kel (/h) | 0.53337 | 0.0536a |
| T1/2 (h) | 1.30 | 12.93a |
AUC0-t, AUC from time zero to the last measured concentration; AUC0-inf, AUC extrapolated to infinity; Kel, terminal elimination rate constant; T1/2, terminal elimination half-life.
a
Value significantly (P < 0.0001) different from that for young rats.