FIGURE 5.

Crystallographic structure of PfUbc9. a, ribbon diagram of the determined structure of PfUbc9 with secondary structures comprising the predicted E1 interface numbered. The active site cysteine is highlighted in yellow. b and c, electrostatic surface representations of the α1 helix and β1-β2 loop regions of PfUbc9 and HsUbc9. Electrostatic potentials were calculated using APBS (52) and colored from positive (+5kT/e; blue) to negative (−5kT/e; red). d, specific divergent residues in the α1 helix and β1-β2 loop region of HsUbc9 and PfUbc9 are indicated.