TABLE 1.
Presence of METTL21A-like sequences in various organisms
| Closest METTL21A homolog |
Reciprocal BLAST versus human (expect value) |
|||||
|---|---|---|---|---|---|---|
| Organism | Expect value | Accession no. | METTL21A (NP_660323.3) | METTL21B (NP_056248.2) | METTL21C (NP_001010977.1) | METTL21D (NP_078834.2) |
| Vertebrates | ||||||
| H. sapiens (human) | NP_660323.3 | 1E-161a | 1E-48 | 6E-23 | 5E-28 | |
| Mus musculus (mouse) | 3E-133 | NP_080240.1 | 5E-145 | 3E-47 | 2E-24 | 3E-25 |
| D. rerio (zebrafish) | 1E-80 | NP_001013584.1 | 2E-92 | 4E-49 | 5E-26 | 3E-24 |
| Gallus gallus (chicken) | 2E-94 | XP_421949.1 | 3E-106 | 4E-43 | 2E-28 | 5E-26 |
| Insects | ||||||
| Acyrthosiphon pisum (pea aphid)b | 5E-20 | XP_001945214.1 | 5E-22 | 5E-25 | 4E-15 | 2E-38 |
| Drosophila melanogaster (fruit fly) | 4E-07 | NP_573368.2 | 9E-9 | 5E-11 | 0.00002 | 0.024 |
| Nematodes | ||||||
| A. suum (pig roundworm)b | 5E-31 | ADY46645.1 | 5E-33 | 1E-22 | 3E-11 | 1E-10 |
| C. elegans | 6E-10 | NP_001122759.1 | 7E-12 | 9E-21 | 7E-13 | 5E-29 |
| Plants | ||||||
| Z. mays (maize)b | 1E-25 | NP_001142219.1 | 2E-27 | 2E-20 | 3E-18 | 9E-25 |
| A. thaliana (thale cress) | 1E-21 | AAU94386.1 | 2E-23 | 2E-24 | 3E-18 | 4E-24 |
| Fungi | ||||||
| Serpula lacrymans (dry rot fungus)b | 7E-29 | EGO01576 | 1E-30 | 3E-18 | 2E-14 | 4E-28 |
| S. cerevisiae (budding yeast) | 1E-17 | NP_014374.1 | 1E-19 | 5E-13 | 2E-11 | 2E-16 |
| S. pombe (fission yeast) | 9E-11 | NP_593178.1 | 2E-12 | 6E-11 | 4E-8 | 1E-14 |
| Othersc | ||||||
| Crassostrea gigas (Pacific oyster) | 7E-69 | EKC35706.1 | 9E-71 | 3E-44 | 4E-22 | 4E-24 |
| N. vectensis (starlet sea anemone) | 7E-64 | XP_001623378.1 | 8E-66 | 2E-34 | 1E-22 | 4E-30 |
| Strongylocentrotus purpuratus (sea urchin) | 4E-51 | XP_781765.3 | 4E-58 | 7E-31 | 1E-22 | 1E-17 |
a Boldface indicates best human hit in a reciprocal search.
b Best hit within a group (insect, nematode, etc.).
c Best hits among invertebrates.