TABLE 1.
ED50 in PK titration assays of PrPSc purified from each CJD type tested
ED50 is expressed as mean ± S.D. Statistical significance was evaluated by means of Kruskal-Wallis one-way ANOVA on ranks followed by pairwise multiple comparisons (Q value estimated with Dunn's method; Q critical value = 3.124 for p < 0.05). Statistically significant comparisons included vCJD versus VV1 (Q = 3.811), VV2 versus VV1 (Q = 4.346), VV2 versus MM1 (Q = 3.309), and MV 2K versus VV1 (Q = 3.642).
| CJD type | Sample size (n) | ED50 |
|---|---|---|
| units/ml | ||
| VV1 | 6 | 0.034 ± 0.028 |
| VPSPr | 2 | 0.069 ± 0.010 |
| MM1 | 6 | 0.093 ± 0.068 |
| MM 2T | 4 | 0.134 ± 0.089 |
| MM 2C | 6 | 0.276 ± 0.210 |
| MV 2K | 7 | 1.407 ± 0.892 |
| VV2 | 6 | 4.137 ± 3.562 |
| vCJD | 3 | 5.192 ± 2.378 |