Table 1. Genotype and allele frequencies of the 5-HTTLPR and rs25531 polymorphisms in EA and AA populations.
|
Populations |
Genotype frequency | Test of differences between all genotypes | Risk allele frequency | Rare allele frequency | Test of differences between all alleles | ||||
|---|---|---|---|---|---|---|---|---|---|
| 5-HTTLPR | ‘L/L' | ‘L/S' | ‘L/xL' | ‘S/S' | ‘xL/S' | ‘S' | ‘xL' | ||
| EA | 868 (33.1%) | 1240 (47.39%) | 1 (0.04%) | 510 (19.45%) | 3 (0.11%) | χ2=236.777, df=4, P=0.0001 | 0.43 | 0.0008 | χ2=124.06, df=2, P=0.0001 |
| AA | 504 (52.8%) | 358 (37.53%) | 27 (2.86%) | 60 (6.29) | 5 (0.52%) | 0.25 | 0.017 | ||
| rs25531 | ‘A/A' | ‘A/G' | ‘G/G' | ‘G' | |||||
| EA | 2236 (85.4%) | 371 (14.2%) | 12 (0.5%) | χ2=251.14, df=2, P=0.0001 | 0.075 | χ2=126.65, df=1, P=0.0001 | |||
| AA | 590 (61.8%) | 329 (34.5%) | 35 (3.7%) | 0.21 | |||||
Abbreviations: AA, African American; EA, European American; L, long allele; S, short allele.