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. 2013 Sep 27;4:116. doi: 10.3389/fphar.2013.00116

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Copyright © Ke, Lei, Wang and Solaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endothelial barrier dysfunction is inhibited by expression of constitutively active Pak1 mediated by recombinant adenovirus (AdPak1) through dephosphorylation of MLC₂₀. (A) Pak1 reduces thrombin mediated decrease of trans-endothelial electrical resistance as measured by ECIS; (B) Bar graph representation of results in A indicates that resistance drop induced by thrombin is rescued by Pak1; (C) Pak1 reduces phosphorylation of myosin regulatory light chain (MLC₂₀) at both threonine 18 and serine19 through activation of PP2A. M, phosphorylated MLC₂₀ as marker; Ctrl, control; AdPak1, recombinant adenovirus expressing constitutively active Pak1.