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. 2013 Oct 1;126(19):4349–4357. doi: 10.1242/jcs.125328

Fig. 8.

Fig. 8.

Src is essential for overloading induced TACE activation, myogenic differentiation and regeneration in mouse soleus. Adult Src+/− mice and wild-type (WT) littermates were subjected to bilateral ablation of the gastrocnemius. Myogenin expression on day 5 (A) and embryonic MHC (eMHC) expression on day 10 (B) of overloading were compared by immunohistochemistry of cross sections of soleus. The percentage of myofibers that express myogenin or eMHC in overloaded soleus are quantified in the bar graph. Cross sections of soleus that had been overloaded for 10 days were stained by H&E (C). Centralized nuclei were counted as an indication of regeneration. Scale bars: 100 µm. Data were analyzed by Student's t-test, *P<0.05 compared with wild-type soleus.