Table 1.
Sample Characteristics for 754 Early-Onset Prostate Cancer Cases
| Clinical Features | EO Cases | Range | |
|---|---|---|---|
| n=754 | % | ||
| Age at Diagnosis (years) 1, | 49.8 (3.9) | 50.5 | 34–55 |
| 34 – 45 | 105 | 13.9 | |
| 46 – 50 | 272 | 36.1 | |
| 51 – 55 | 377 | 50.0 | |
| Number of Affected Family Members 1,2 | 1.4 (1.8) | 1 | 0 – 17 |
| 0 | 273 | 36.2 | |
| ≥ 1 | 481 | 63.8 | |
| Family History of Prostate Cancer | |||
| 1st degree relative (confirmed) | 310 | 41.1 | |
| 2nd degree relative (confirmed) | 83 | 11.0 | |
| 1st or 2nd degree relative (unconfirmed) | 73 | 9.7 | |
| 3rd degree relative (unconfirmed) | 15 | 2.0 | |
| Serum PSA (ng/mL) 1,3 | 22.9 (218.7) | 5.4 | 0.3 – 5428 |
| < 4.0 | 172 | 24.0 | |
| 4.0–9.9 | 403 | 56.1 | |
| ≥ 10 | 143 | 19.9 | |
| Gleason Score 1 | 6.4 (0.9) | 6.0 | 3 – 10 |
| 3–6 | 446 | 61.0 | |
| 7 | 227 | 31.1 | |
| 8–10 | 58 | 7.9 | |
| Aggressive Disease 4 | |||
| No | 529 | 70.2 | |
| Yes | 225 | 29.8 | |
1
For age at diagnosis, number of affected family members, and serum PSA statistics given are: mean (SD), median, and range.
2
Total numbers of affected family members, not including the proband.
3
Serum prostate-specific antigen (PSA) measured at diagnosis prior to treatment.
4
Aggressive disease defined as in Lange et al., 2005. (1)