Table 2.
Early Onset Prostate Cancer Risk Associated With SNPs When Compared with iControlDB Public Controls.
| SNP | Chr. | Alleles1 | Frequency of Risk Allele | OR (95 %CI)2 | P (two-sided) | P (one-sided)3 | |
|---|---|---|---|---|---|---|---|
| Early-Onset Cases (n=754) | iControls (n=2,713) | ||||||
| rs2660753 (14) | 3p | C/T | 0.127 | 0.140 | 0.90 (0.76,1.07) | 0.22 | 0.89 |
| rs9364554 (14) | 6q | C/T | 0.317 | 0.259 | 1.32 (1.17,1.50) | 1.3×10−05 | 6.3×10−06 |
| rs10486567 (16) | 7p | A/G | 0.806 | 0.761 | 1.30 (1.12,1.49) | 4.0×10−04 | 2.0×10−04 |
| rs6465657 (14) | 7q | T/C | 0.495 | 0.451 | 1.19 (1.06,1.34) | 0.0029 | 0.0015 |
| rs1447295 (26) | 8q | C/A | 0.134 | 0.099 | 1.41 (1.18,1.67) | 1.7×10−4 | 8.7×10−5 |
| rs6983267 (19) | 8q | T/G | 0.606 | 0.499 | 1.55 (1.38,1.75) | 1.9×10−13 | 9.6×10−14 |
| rs1571801 (25) | 9q | G/T | 0.274 | 0.245 | 1.16 (1.02,1.32) | 0.024 | 0.012 |
| rs4962416 (16) | 10q | A/G | 0.326 | 0.295 | 1.15 (1.02,1.30) | 0.023 | 0.012 |
| rs10993994 (16) | 10q | C/T | 0.470 | 0.422 | 1.21 (1.08,1.36) | 0.0011 | 5.5×10−04 |
| rs7931342 (14) | 11q | T/G | 0.578 | 0.544 | 1.15 (1.03,1.30) | 0.017 | 0.0083 |
| rs1859962 (17) | 17q | T/G | 0.534 | 0.474 | 1.26 (1.12,1.41) | 6.4×10−05 | 3.2×10−05 |
| rs4430796 (17) | 17q | C/T | 0.571 | 0.499 | 1.31 (1.17,1.47) | 3.2×10−06 | 1.6×10−06 |
| rs2735839 (14) | 19q | A/G | 0.888 | 0.849 | 1.39 (1.18,1.67) | 1.9×10−04 | 9.3×10−05 |
| rs5945619 (14) | Xp | T/C | 0.432 | 0.364 | 1.33 (1.13,1.57) | 7.9×10−04 | 3.9×10−04 |
1
Reference allele/allele associated with increased risk of prostate cancer in prior studies.
2
Odds Ratio for each additional copy of risk allele (as identified in previous studies) assuming a multiplicative model.
3
One-sided test for direction of alternative hypothesis determined by prior study.