Table 3.

Association between MUC5AC rs1132440 genotypes and respiratory outcomes

Outcome	Genotypes (CC versus)	Before adjustment		After adjustment		n
		OR (95% CI)	P-value	OR (95% CI)	P-value
Ever bronchitis 1989†	GC	1.042 (0.83–1.30)	0.717	1.033 (0.83–1.29)	0.779	2361
	GG	0.689 (0.50–0.94)	0.019	0.683 (0.50–0.93)	0.017
Wheeze 1989 ‡	GC	0.938 (0.64–1.37)	0.739	0.898 (0.61–1.32)	0.582	2285
	GG	0.382 (0.20–0.74)	0.005	0.372 (0.19–0.73)	0.004
Ever asthma 1999	GC	0.975 (0.73–1.31)	0.865	0.979 (0.73–1.31)	0.887	2362
	GG	0.614 (0.40–0.94)	0.025	0.615 (0.40–0.94)	0.026
Ever hay fever 1999	GC	1.220 (0.99–1.51)	0.068	1.242 (1.00–1.54)	0.049	2357
	GG	0.930 (0.70–1.23)	0.614	0.949 (0.71–1.26)	0.721

Outcomes are described in Table 1. Logistic regression OR and P-values are shown both before and after adjusting for the possible confounders; smoking status, region of birth, father's social class, own social class, gender. Significant associations are shown in bold and OR 95% confidence intervals are in parentheses.

^†Note that this variable does not exist for 1999.

^‡Wheeze most days and nights; was not statistically significant in 1999.

CI, confidence interval; OR, odds ratio.