Fig. 2.

Mutations in the Ras-PI(3)K-mTOR axis in WHO grade IV astrocytoma. Shown are all confirmed somatic or previously reported mutations that have been listed in COSMIC v54 under astrocytoma grade IV. The y-axis indicates the number of times a particular mutant has been observed in a primary tumor sample, xenograft tumor, or cell line. Missense mutations are shown in black; nonsense and frameshift mutations as well as small in-frame insertions and deletions are shown in red. Recurrent deletions/truncations in the coding regions of EGFR and PDGFRA are indicated in shaded gray and their estimated frequency is shown as percent of all GBMs (right y-axis)