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| Variable Heavy Chaina | Variable Light Chaina | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FW1 | CDR1 | FW2 | CDR2 | FW3 | FW1 | CDR1 | FW2 | CDR2 | FW3 | CDR3 | ||||||||
| Clone | 3 | 11 | 32 | 45 | 49 | 51 | 65 | 67 | 82 | 1 | 5 | 24 | 32 | 39 | 53 | 72 | 84 | 97 |
|
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| 2C12.4 | T | I | S | L | L | I | S | L | I | D | T | R | Y | K | N | T | A | T |
|
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| H8 | S | V | N | S | K | F | R | |||||||||||
| E4 | V | P | S | F | R | S | T | |||||||||||
| F4 | A | P | S | V | N | S | K | F | R | |||||||||
| G8 | S | G | T | N | S | K | F | A | R | |||||||||
Amino acid substitutions based on Kabat numbering. FW, framework; CDR, complementary determining region
