Table 5.
Univariate Analysis of Prognostic Factors
| Variable | p – value | Hazard ratio (95% CI) |
|---|---|---|
|
| ||
| Age as a continuous variable | 0.0847 | 1.011 (0.998–1.024) |
|
| ||
| Male | 0.5731 | 0.916 (0.677–1.241) |
|
| ||
| White | 0.0687 | 1.574 (0.966–2.567) |
|
| ||
| Asian | 0.1657 | 0.605 (0.298–1.231) |
|
| ||
| History of smoking | 0.0120 | 0.683 (0.507–0.920) |
|
| ||
| Tumor size (cm) | 0.0002 | 1.088 (1.040–1.138) |
|
| ||
| AJCC/UICC T status | <.0001 | 1.811 (1.486–2.207) |
|
| ||
| AJCC/UICC N status | <.0001 | 1.979 (1.683–2.327) |
|
| ||
| AJCC/UICC M status | <.0001 | 3.319 (2.335–4.719) |
|
| ||
| Overall AJCC/UICC stage | <.0001 | 1.952 (1.672–2.278) |
|
| ||
| N ratio | <.0001 | 10.061 (6.286–16.103) |
|
| ||
| Tumor location compared to Antrum | ||
| GE junction/Cardia | 0.0052 | 1.684 (1.168–2.427) |
| Fundus/body | 0.1855 | 1.276 (0.889–1.832) |
| Diffuse | 0.0022 | 4.998 (1.782–14.016) |
|
| ||
| Borrmann classification compared to Polypoid | ||
| Fungating | 0.9864 | 1.005 (0.556–1.817) |
| Ulcerated | 0.2678 | 1.307 (0.814–2.099) |
| Infiltrative | 0.0307 | 1.878 (1.060–3.327) |
|
| ||
| Lymphovascular invasion | <.0001 | 2.666 (1.710–4.156) |
|
| ||
| Venous invasion | <.0001 | 2.730 (1.807–4.122) |
|
| ||
| Perineural invasion | 0.0002 | 2.296 (1.482–3.558) |
|
| ||
| Positive margin | <.0001 | 3.211 (2.234–4.615) |
|
| ||
| 15 or greater nodes examined | 0.4941 | 1.109 (0.824–1.492) |
|
| ||
| Poorly differentiated or undifferentiated tumor | 0.0125 | 1.515 (1.094–2.100) |
|
| ||
| Chemotherapy | 0.9894 | 0.998 (0.740–1.346) |
|
| ||
| Radiation therapy | 0.0655 | 0.741 (0.539–1.019) |