Figure 2.
Kinetic study of the course of collagen arthritis in the knee joint after intra-articular injection of Ad5E1mIL-4 and Ad5del70-3. Collagen type II–immunized DBA-1 mice were injected intra-articularly in the right knee joint with 1.107 pfu of either Ad5E1mIL-4 or Ad5del70-3 before onset of CIA was noted. At days 1, 3, 5, and 7 after intra-articular injection of the viral vector, mice were sacrificed by cervical dislocation, and the skin of the knee joint was removed. The appearance of arthritis in the injected joints was visually scored for severity (arthritis score). Results are the mean ± SD of two separate experiments with a total of at least 22 mice per group. Ad control, Ad5del70-3.