Figure 1.

The DNA sequences and VDJ splice sites of the somatic V_H rearrangements expressed in the EO6 B-cell hybridoma and the T(EPC)15 plasmacytoma, and their relationship to the most homologous germ-line (GL) V_H, D_H, and J_H gene segments. Sequence analysis for the 372 encoding nucleotides of the EO6 V_H rearrangement did not reveal a single nucleotide variation suggestive of somatic hypermutation. The canonical T15/EO6 VDJ rearrangement has been described as an archetype for primary homology-directed recombination, which more frequently occurs during B-lymphogenesis in the fetal liver. CDR: complementarity-determining region.